Glutathione
The body's master antioxidant, a tripeptide that in skincare can help even the look of pigmentation over time.
glutathione, L-glutathione, reduced glutathione, GSH
Pigmentation & dark spots · Dull skin
What it does
Glutathione is one of the most powerful antioxidants used by the human body, found in almost every cell. In skincare it is also used as a brightening ingredient, helping to even out the look of pigmentation.
How it works
A tripeptide, glutathione is formed by three amino acids: glutamic acid, cysteine and glycine. It has been studied for its effect on the look of uneven skin tone and dark spots. Small trials suggest dark spots can look less visible with consistent use. As an antioxidant, it helps neutralise free radicals and recycle other antioxidants, such as vitamins C and E.
MG says
Used consistently, glutathione can help gradually soften the look of existing pigment and keep tone looking even, but it works best as a supporting antioxidant rather than a stand-alone brightener. Hormonal pigmentation is notoriously challenging and rarely responds to one ingredient; in the studio we address it with targeted depigmentation peels such as Cosmelan and Dermamelan.
Cautions
Topical glutathione is generally well tolerated, though the evidence for its brightening effect is still limited compared with vitamin C or niacinamide. Wear SPF daily, as pigment returns quickly without sun protection. If you're pregnant, trying to conceive or breastfeeding, check with your doctor, midwife or pharmacist before using glutathione products. This entry covers skincare only: injectable glutathione is a medicine, not a skincare ingredient, and injections or drips promoted for lightening the skin carry safety concerns.
Regional notes
Australia: Glutathione for injection is a prescription-only (Schedule 4) medicine; topical glutathione in skincare isn’t scheduled.

